Assessment of Reversibility in Pulmonary Hypertension Related to Congenital Heart Disease by Using Biomarkers and Clinical Features

Background: Reversibility of pulmonary hypertension (PH) is closely related to the treatment options for and prognosis children with congenital heart disease. Objective: We combined patient-specific clinical features including diagnosis, age echocardiographic results, biomarkers vascular dysfunction explore noninvasive methods that can be used accurately evaluate reversibility in disease (PH-CHD). Methods: Based on preoperative systolic arterial pressure (sPAP), 70 CHD patients were divided into normal, PH-CHD suspected, confirmed groups. Additionally, circulating endothelial cells (CECs), endothelin-1 (ET-1), nitric oxide synthase (eNOS) detected. Patients categorized reversible (RPH) irreversible (IRPH) groups according sPAP 6 months after surgery. Risk stratification was performed biomarkers. Results: CECs ET-1 levels group significantly higher. eNOS higher suspected than normal group. IRPH compared RPH No such intergroup differences observed respect levels. The ROC curve showed risk high diagnostic value reversibility. Conclusion: CECs, eNOS, PH-CHD. have practical assessing